Joshua has already admitted the fight against Usyk will be a major challenge.
“We are two Olympic gold medallists who have fought our way to the top and never avoided challenges,” said Joshua.
“The venue is exceptional, the atmosphere will be electric, I’m honoured to be the first person to fight in such an awe-inspiring venue. The stage is set and I am ready to handle business.”
Between 60,000 and 80,000 fans could be seated in the Tottenham Hotspur Stadium for the fight, almost certainly setting a new attendance record for the ground.